Yes, but with an important catch. US federal law does not allow the playing of full-motion video on freeway-facing billboards, as it distracts drivers. So if you were picturing your ad looping on the 405, that's a static placement.
But here's where LA gets interesting. The city has designated entertainment zones and independent municipalities, such as Inglewood, the Sunset Strip in West Hollywood, and the LA Live precinct near Crypto.com Arena, where full-motion digital billboards are actually permitted. WOW Media operates a serious network in exactly these spots, including corridors near LAX and SoFi Stadium. High-traffic, high-visibility, and yes, full video.
